[Footnote 4: An interesting notice of "_Inoculation for Smallpox_," in 1794, is to be found in the files of the old _Kentucky Gazette_, a paper published by John Bradford, in Lexington, August 11, 1787--the first newspaper published west of the Alleghany mountains. This notice appeared in that paper January 4, 1794, as follows: "On Thursday last the inhabitants of this place began the inoculation of smallpox and have agreed to continue until the fifteenth, after which they are determined to cease. They have appointed a committee to draw up a remonstrance to the court of Fayette County requesting that the order of that court granting liberty to the inhabitants of said county to inoculate may be rescinded, so far as respects the town of Lexington, after that date." The _Gazette_ for the first of February following has this significant statement, illustrating the great hazard of this primitive operation, viz: "That the smallpox had been very fatal within the three weeks past in the town and vicinity under inoculation, that at least _one out of fifteen died_ who had been inoculated, and very few children had recovered." Vaccination was introduced here by Professor Samuel Brown, M. D., at quite an early period, as we shall see further on.] [Footnote 5: Lexington, January 8, 1799. (See Records of Transylvania University, Volume 1.)] [Footnote 6: December 11, 1799. (See Records of Transylvania University.)] [Footnote 7: "Memoranda of the Preston Family," by John Mason Brown, Page 20.] [Footnote 8: See "Memoranda of the Preston Family," Page 37, for his descendants.] [Footnote 9: Quoted from an introductory lecture to the winter course in the Medical Department of Transylvania University, delivered by the present writer (Doctor Robert Peter) November 5, 1854.] [Footnote 10: Doctor Ridgely was born on Elkridge, Anne Arundel County, Maryland, May 25, 1757, and studied medicine under Doctor Philip Thomas, of almost unrivaled reputation. (Doctor C. W. Short.)] [Footnote 11: Doctor James Fishback resigned as Trustee and qualified as Medical Professor November 4, 1805. (See Records.)] [Footnote 12: Jacob Fishback was a Trustee of Transylvania in 1801 and up to 1807. (See Records.)] [Footnote 13: See Records of Transylvania University, 1809.] [Footnote 14: An able biographical sketch of him by his son, Joseph Buchanan, also celebrated, was published in _Collins' History of Kentucky_, first edition.] [Footnote 15: According to Doctor C. C. Graham he held that these two chairs should be inseparable.] [Footnote 16: Now the site of the golf links at the termination of North Broadway.] [Footnote 17: This was before the use of anesthetics in surgery, it must be remembered.] [Footnote 18: Did he not, in this preliminary preparation of his surgical patients, unwittingly render them safe from the microbes of disease, thus practically securing for them the benefits of more modern scientific discovery?]