The late Professor Rolleston, whose competence as an observer no one is likely to dispute, gave Mr. Darwin two cases as having fallen under his own notice, one of a man whose knee had been severely wounded, and whose child was born with the same spot marked or scarred, and the other of one who was severely cut upon the cheek, and whose child was born scarred in the same place. Mr. Darwin's conclusion was that "the effects of injuries, especially when followed by disease, or perhaps exclusively when thus followed, are occasionally inherited." Let us now see what Professor Weismann has to say against this. He writes:-- "The only cases worthy of discussion are the well-known experiments upon guinea-pigs conducted by the French physiologist, Brown- Sequard. But the explanation of his results is, in my opinion, open to discussion. In these cases we have to do with the apparent transmission of artificially produced malformations. . . . All these effects were said to be transmitted to descendants as far as the fifth or sixth generation. "But we must inquire whether these cases are really due to heredity, and not to simple infection. In the case of epilepsy, at any rate, it is easy to imagine that the passage of some specific organism through the reproductive cells may take place, as in the case of syphilis. We are, however, entirely ignorant of the nature of the former disease. This suggested explanation may not perhaps apply to the other cases; but we must remember that animals which have been subjected to such severe operations upon the nervous system have sustained a great shock, and if they are capable of breeding, it is only probable that they will produce weak descendants, and such as are easily affected by disease. Such a result does not, however, explain why the offspring should suffer from the same disease as that which was artificially induced in the parents. But this does not appear to have been by any means invariably the case. Brown- Sequard himself says: 'The changes in the eye of the offspring were of a very variable nature, and were only occasionally exactly similar to those observed in the parents.' "There is no doubt, however, that these experiments demand careful consideration, but before they can claim scientific recognition, they must be subjected to rigid criticism as to the precautions taken, the nature and number of the control experiments, etc. "Up to the present time such necessary conditions have not been sufficiently observed. The recent experiments themselves are only described in short preliminary notices, which, as regards their accuracy, the possibility of mistake, the precautions taken, and the exact succession of individuals affected, afford no data on which a scientific opinion can be founded" (pp. 81, 82).