The earliest symptom of approaching grease is enlargement of the legs, accompanied by considerable heat of the skin. If the animals be now observed, they will be seen to be uneasy in their stalls; the hinder feet are occasionally noisily stamped upon the pavement. Should the hair be examined, it will be discovered loaded with scurf about the roots, while one hind foot will be frequently seen employed to scratch the back of the opposite leg. Should these indications attract no attention, the hairs soon begin to stand on end or to project outward, as though each was actuated by a separate purpose, and each desired nothing so much as to avoid its fellows. At the same time, the part begins to exude a thick, unctuous moisture, from which the disease derives its name. This hangs upon all the hairs of the heel in heavy drops. It is an offensive secretion. It emits a remarkably pungent and a very peculiar odor, which, once inhaled, is never afterward to be forgotten. [Illustration: FIRST STAGE OF CONFIRMED GREASE. EXUDATION.] [Illustration: THE SECOND STAGE OF CONFIRMED GREASE. CRACKS.] Should no regard be now bestowed upon the sufferer, and should the horse be worked on despite the lameness which it now exhibits, the skin swells, while cracks, deep and wide, appear upon the inflamed integument. The lines of division ulcerate, sometimes very badly; a thin, discolored, and unhealthy pus mingles with the discharge; the odor grows still more abominable, while the wretched animal becomes yet more lame. [Illustration: THE THIRD STAGE OF CONFIRMED GREASE. HORNY BUNCHES WHICH ARE COMMONLY CALLED GRAPES. ] Should, even at this period, no proper remedy be applied to check the disease, the leg enlarges. Proud flesh, or fungoid granulations, sprout from the lines of ulceration. The granulations grow in bunches, and have a ragged surface. Often the masses are of great size, and shake, as though about to fall, with every movement of the foot. The points, from exposure, become dry and hard; their nature, from that of fungoid granulations, changes to a substance resembling horn, like which, they are without sensation. These bunches have been named "grapes," which they are vulgarly thought to resemble. The likeness, however, is very distant--the one being pleasant to look upon, the other forming a painful and disgusting spectacle.