A horse, full of corn, and in the prime of health, if unfortunately inoculated with the virus of glanders, generally has the disease in its acutest form: the animal may be dead by the expiration of a week. Other quadrupeds, in which the disorder is provoked by natural causes, may, on the contrary, exhibit glanders in the most chronic shape. If the exciting cause has a strong constitution to act upon--especially if the horse, soon after imbibing the poison, be removed to easier work or a more dry abode--the malady may exist for years in a subtle, undeveloped form. A thin discharge only may run, irregularly, from one nostril. At times no fluid may appear, nor is the liquid ever copious. One of the kernels, or lymphatic glands, situated between the branches of the channel, may be more or less fixed. But, otherwise, the horse is active, full of fire, and exhibits nothing to excite suspicion. During all this time the creature may be endowed with a fatal power of communicating the disease. Horses, having received the taint from such a source, may die within the week, while the cause of the mortality eats well, works well, delights the master's eye by its thriving appearance, and in such a condition even may exist for years. [Illustration: THE HEAD OF A HORSE WHICH HAD BEEN SLAUGHTERED FOR GLANDERS. 1. The lymphatic gland enlarged, hard, and adherent firmly to the interior of the jaw-bone. ] In the early stage it is difficult to pronounce positively upon a case of glanders. Ulceration of the nasal membrane would be confirmation of the worst doubt; but the ulceration may be situated so high up as to defy all our efforts to distinguish it. Yet running from the nose may be perceptible, and the gland may be fixed to the jaw. Both of these symptoms, although lawfully provoking our fears, are frequently attendant upon aggravated or upon prolonged colds. The only lawful test, in such cases, is the administration of three doses of solution of aloes, eight ounces to the dose--allowing three days to elapse between each. If the horse be glandered, before the last purgative has set the real nature of the malady will be apparent in the aggravation of the symptoms. If glanders be not present, a little careful nursing will generally remove all effect of the medicine. The glanders is mostly ushered in by febrile disturbance. The appetite is bad, the coat stares, and the pulse is quickened. A mash or two, however, apparently sets all right, and the matter is forgotten. Soon afterward a slight discharge may issue from one nostril; but it is so very slight, it excites no alarm. One of the lymphatic glands, on the same side as the moist nostril, alters in character. It may remain loose and become morbidly sensitive. Usually, however, it grows adherent to the jaw, turns hard, insensitive, and, from being wholly imperceptible in the healthy animal, enlarges to about the size of half a chestnut.