The wing of the nostril being raised, the examiner must note the appearances exposed; this he will best do by knowing where to look and what to expect. His eye has nothing to do with the skin nor with the marks that appear upon it. The opening of the lachrymal duct often challenges observation by being well defined and particularly conspicuous; but that natural development does not concern him; to that no attention must be given. The inspection must be concentrated upon the membrane more internally situated than the skin seen at the commencement of the nostrils. The skin, moreover, suddenly ceases, and is obviously defined by a well-marked margin; there is, therefore, no difficulty in distinguishing the membrane by its fleshy and moistened aspect, as well as by its situation. If, on this membrane, any irregular or ragged patches are conspicuous, if these patches are darker toward their edges than in their centers, and if they, nevertheless, seem shallow, pallid, moist, and sore, the animal may be rejected as glandered. Should any part of the membrane--after being wiped as before directed--seem rough or have evidently beneath its surface certain round or oval-shaped bodies, the horse assuredly is glandered. The membrane may present a worm-eaten appearance, or be simply of a discolored and heavy hue. In the first case, the animal ought to be condemned; in the second, it is open to more than suspicion. No animal should be permitted to slowly perish of glanders. The disease, as it proceeds, affects the fauces, pharynx, and larynx; all become ulcerated. Not a particle of food can be swallowed; not a drop of saliva can be deglutated; not a breath of air can be inspired, without the severest torture being experienced. As the disease proceeds, the obstruction offered to the breathing grows more and more painful. Farcy breaks forth, and, as a consequence, superficial dropsy is added to the other torments. The edges of the nostrils enlarge; the membrane lining the cavities bags out, while the fauces and larynx contract: the discharge becomes more copious and the breathing is impeded. Thus the difficulty of respiration is increased, just as the condition of the lungs renders the necessity of pure air the more imperative. Ultimately, however, laborious breathing induces congestion of the brain, and the wretched sufferer falls insensible--it is hoped--to die of actual suffocation.