Students of philosophy will recognize what I mean when I say that this growing conviction of futility and consequent distaste are associated with the outcome of the famous dictum of Kant, that perception without conception is blind, while conception without perception is empty. The whole course of reflection since Kant’s time has tended to justify this remark. The sensationalist and the rationalist have worked themselves out. Pretty much all students are convinced that we can reduce knowledge neither to a set of associated sensations, nor yet to a purely rational system of relations of thought. Knowledge is judgment, and judgment requires both a material of sense perception and an ordering, regulating principle, reason; so much seems certain, but we do not get any further. Sensation and thought themselves seem to stand out more rigidly opposed to each other in their own natures than ever. Why both are necessary, and how two such opposed factors coöperate in bringing about the unified result of science, becomes more and more of a mystery. It is the continual running up against this situation which accounts for the flagging of interest and the desire to direct energy where it will have more outcome. This situation creates a condition favorable to taking stock of the question as it stands; to inquiring what this interest, prolonged for over three centuries, in the possibility and nature of knowledge, stands for; what the conviction as to the necessity of the union of sensation and thought, together with the inability to reach conclusions regarding the nature of the union, signifies. I propose then to raise this evening precisely this question: What is the meaning of the problem of knowledge? What is its meaning, not simply for reflective philosophy or in terms of epistemology itself, but what is its meaning in the historical movement of humanity and as a part of a larger and more comprehensive experience? My thesis is perhaps sufficiently indicated in the mere taking of this point of view. It implies that the abstractness of the discussion of knowledge, its remoteness from everyday experience, is one of form, rather than of substance. It implies that the problem of knowledge is not a problem that has its origin, its value, or its destiny within itself. The problem is one which social life, the organized practice of mankind, has had to face. The seemingly technical and abstruse discussion of the philosophers results from the formulation and statement of the question.