From all secular things and persons he kept entirely aloof. Of the events then passing in the world, nothing stirred his curiosity or his interest but the ruthless crusade against heresy, led by Cardinal Valdes, the fiercest inquisitor since the days of Torquemada. For the great northern Reformation had made itself felt, though with feeble and transient effect, even in Spain,--as the Lisbon earthquake troubled the waters of Lochlomond. Strange questions were stirred in the schools of Alcala and Salamanca; new doctrines were taught from the pulpits of Seville and Valladolid; wool-clad wolves were said to lurk even in the folds of St. Francis and St. Dominic; and Lutheran traders ran casks of heretical tracts upon the shores of the bay of Cadiz. Amongst the persons arrested at Valladolid was Dr. Augustin Cazalla, canon of Salamanca, who had been one of the emperor's preachers, and as such, had resided, from 1546 to 1552, at the imperial court in Germany. Though he had distinguished himself in the land of the Reformation by sermons against its doctrines, and had returned to Spain with untarnished orthodoxy, he was accused not only with being infected with Lutheran principles, but of having "dogmatized," as the inquisition happily called preaching, in a conventicle at Valladolid. Charles was much moved when he heard of his arrest, not with pity for the probable fate of the man, but with horror of his crime. "Father," said he to the prior, "if there be any thing which could drag me from this retreat, it would be to aid in chastising heretics. For such creatures as these, however, this is not necessary; but I have written to the inquisition to burn them all, for none of them will ever become true Catholics, or are worthy to live." This recommendation, seldom neglected, was exactly observed in the case of the poor chaplain. Denying the offence of dogmatizing, he confessed having held heretical opinions, and offered to abjure them. Nevertheless he was "relaxed," or in secular speech, burnt, with thirteen companions, at Valladolid, in the presence of the princess-regent and her court.