A most characteristic feature, which has been made out by the careful study of these trypanosomes by means of colouring reagents and very high powers of the microscope, is that, whilst there is a large granular nucleus there is also a small body at the anterior end of the animalcule which readily stains and is placed at the end of the root (so to speak) of the vibratile _flagellum_ or free thread. This smaller nucleus has been variously called the “micronucleus,” the “centrosome,” and the “blepharoplast.” It is identical with a structure similarly placed in non-parasitic microscopic animals to which trypanosoma is undoubtedly related. We find it in the phosphorescent noctiluca of our seas, and in various animalcules called “Flagellata.” [Illustration: FIG. 51. The Trypanosome (_T. equiperdum_) of the disease called “Dourine,” as seen alive in the blood of a rat, eight days after inoculation. A, the actively wriggling cork-screw-like parasites; B, the blood-corpuscles of the rat. This figure, of comparatively low magnification, gives an indication of the relative size of the parasites and the blood-corpuscles. The blood-corpuscles are about 1/5000th of an inch each in diameter.] The creature drawn in our fig. 50 is, then, the typical trypanosome. It is this which the medical investigator looks for in his human or animal patients; it is this which he has regarded as the sign and proof of infection. Experiments have shown that, though so much alike in appearance in the different diseases we have named, yet each trypanosome has its own properties. Human blood-serum is poisonous to one and not to another; an animal immune to one is not immune to another. At present no treatment has been discovered which will destroy the parasites when once they have effected a lodgment, or act as an antidote to the poison which they produce in the infected animal or man. But the fact that in some cases an animal may become immune to the attack of the parasite which usually is deadly to its kind, gives hope of an eventual curative treatment for trypanosome infection; as does also the fact that the serum of some animals acts as a poison to trypanosomes which flourish in other animals. With regard to immunity, it must always be remembered that we are liable to confuse two different conditions under this one term. An animal may be said to be immune to blood-parasite because that parasite is actually unable to live in its blood. On the other hand an animal is often said to be immune to a parasite when the parasite can and does flourish in its blood or tissues but produces no poisonous effect. A more precise nomenclature would describe the attacked organism in the first case as “repellent,” for it repels the parasite altogether; in the second case as “tolerant,” for it tolerates the presence and multiplication of the parasite without suffering by it.