Infectious disease, it was long ago pointed out, must be studied from three main points of view: (1) the life history and nature of the disease-germ or infective matter; (2) the infected subject, his repellant or tolerant possibilities, and his predisposition or receptivity; (3) the intermediary or carrying agents. Whilst it is true that little or nothing has been done by the State in acquiring or making use of knowledge as to the first and second of these factors, with a view to controlling the spread of disease, it is the fact that much has been done both in the way of investigation and administration in relation to the third factor. The great public-health enquiries and consequent legislation in this country, in which scientific men of the highest qualifications, such as Simon, Farr, Chadwick, and Parkes, took part during the Victorian period, have had excellent results; to them are due the vast expenditure at the present day on pure water, sewage disposal, and sanitary inspection. But little or nothing has been done in regard to the first and second divisions of the subject, in which the less organised portions of the British Empire are more deeply concerned than in waterworks and sewer-pipes. It is still contested whether leprosy (which is a serious scourge in the British Empire, though expelled from our own islands) is a matter of predisposition caused by diet or solely due to contagion; and yet it is left to individual practitioners to work out the problem. The State prepares vaccine lymph in a cheap and unsatisfactory way for the use of its, till recently, compulsorily vaccinated citizens; but the State, though thus interfering in the matter of vaccine, has spent no money to study effectively and so to improve the system of vaccination. Here and there some temporary and ineffective enquiry has been subsidised by a Government office; but there is no great army of investigators working in the best possible laboratories, led by the ablest minds of the day, with the constant object of improving and developing in new directions the system of inoculation. Surely if compulsion, or every pressure short of compulsion, is justified in enforcing vaccine inoculation on every British family, it would be only reasonable and consistent to expend a million or so a year in the perfection and intelligent control of this remedy by the most skilled investigators. Yet not a halfpenny is spent by the British Government in this way. Medicine is organised in this country by its practitioners as a fee-paid profession; but as a necessary and invaluable branch of the public service it is neglected, misunderstood, and rendered to a large extent futile by inadequate funds and consequent lack of capable leaders. The defiant desperate battle which civilised man wages with Nature must go on; but man’s suffering and loss in the struggle--the delay in his ultimate triumph--depend solely on how much or how little the great civilised communities of the world seek