Mrs. Cockburn, after her marriage, was entirely diverted from her studies for many years, by attending tending upon the duties of a wife and a mother, and by the ordinary cares of an encreasing family, and the additional ones arising from the reduced circumstances of her husband. However, her zeal for Mr. Lock's character and writings drew her again into the public light in 1716, upon this occasion. Dr. Holdsworth, fellow of St. John's College in Oxford, had preached on Easter-Monday, 1719 20, before that university, a sermon on John v. 28, 29, which he published, professing in his title page to examine and answer the Cavils, False Reasonings, and False Interpretations of Scripture, of Mr. Lock and others, against the Resurrection of the Same Body. This sermon did not reach Mrs. Cockburn's hands 'till some years after; when the perusal of it forced from her some animadversions, which she threw together in the form of a letter to the Dr. and sent to him in May 1724, with a design of suppressing it entirely, if it should have the desired effect upon him. After nine months the Dr. informed her, that he had drawn up a large and particular answer to it, but was unwilling to trust her with his manuscript, 'till she should publish her own. However, after a long time, and much difficulty, she at last obtained the perusal of his answer; but not meeting with that conviction from it, which would have made her give up her cause, she was prevailed on to let the world judge between them, and accordingly published her Letter to Dr. Holdsworth, in January 1726 7, without her name, but said in the title page to be by the author of, A Defence of Mr. Lock's Essay of Human Understanding. The Dr. whose answer to it was already finished, was very expeditious in the publication of it in June 1727, in an 8vo volume, under the title of A Defence of the Doctrine of the Resurrection of the same Body, &c. Mrs. Cockburn wrote a very particular reply to this, and entitled it, A Vindication of Mr. Lock's Principles, from the injurious Imputations of Dr. Holdsworth. But though it is an admirable performance, and she was extremely desirous of doing justice to Mr. Lock and herself, yet not meeting with any Bookseller willing to undertake, nor herself being able to support the expence of the impression, it continued in manuscript, and was reserved to enrich the collection published after her death.