In the region of the Abruzzi, in Italy, more especially in the province of Teramo, wonderful virtues are attributed to the intercession of St. Donato. So great is thought to be his power to cure those afflicted with epilepsy that in this region the disease is called the malady of St. Donato. This saint, however, is credited with much more extensive powers, for he is believed to cure hydrophobia, to prevent the ill effects of the Evil Eye, and in general to bring to naught the enchantments of witches. Such being his powers, it is not surprising that his image was added to many amulets, those figuring the lunar crescent being frequently surmounted with the bust of the saint. This type of amulet owes its supposed efficacy to the horn-like shape of the crescent, horns or substances having a likeness to a horn, like certain branches of coral, being regarded as a sure protection against the Evil Eye. A curious amulet bears the bust of St. Donato surmounting a crescent moon within which is the dreaded number thirteen. This fateful number is considered to be a source of misfortune for those who do not wear it inscribed on an amulet; but it becomes a source of good fortune and a happy life for those who possess such an amulet.[504] A notable instance of the use of a saint’s name to facilitate the perpetration of a crime is afforded in the case of the poison known as Aqua Tofana. This appears to have been a preparation of arsenic and was concocted by a woman named Tofana, a native of Palermo, in Sicily, who eventually took up her abode in Naples and devoted herself to the preparation and sale of her poison in Naples, Rome and elsewhere. To divert suspicion she used vials marked “Manna of St. Nicholas of Bari,” and bearing the image of this saint. Most of her clients are said to have been women who were anxious to rid themselves of their husbands, and she must have had a large practice in this specialty, for so many husbands died in Rome in a mysterious manner that in 1659 the authorities finally took cognizance of the matter and instituted a searching investigation. This revealed the fact that there existed in Rome a secret society entirely composed of women who wished to “remove” their husbands by poison. The leader of this society and many of the members were duly executed, but Tofana does not seem to have been molested.