I am not altogether of their mind, that absolutely reject the internal use of Leaf-Gold, Rubies, Saphyrs, Emeralds, and other Gems, as things that are unconquerable by the heat of the stomach. For as there are rich Patients that may, without much inconvenience, goe to the price of the dearest Medicines; so I think the Stomach acts not on Medicines barely upon the account of its heat, but is endowed with a subtle dissolvent (whence never it hath it) by which it may perform divers things not to be done by so languid a heat. And I have, with Liquors of differing sorts, easily drawn from Vegetable Substances, and perhaps unrectified, sometimes dissolved, and sometimes drawn Tinctures from Gems, and that in the cold.... But that which I chiefly consider on this occasion is, that ’tis one thing to make it _probable_, that is, _possible_, Gold, Rubies, Saphyrs, etc., may be wrought upon by humane Stomach; and another thing to shew both that they _are wont_ to be so, and that they _are_ actually endowed with those particular and specifick Virtues that are ascribed to them; nay and (over and above) that these Virtues are such and so eminent, that they considerably surpass those of cheaper Simples. And I think, that in Prescriptions made for the poorer sort of Patients, a Physician may well substitute cheaper Ingredients in the place of these precious ones, whose Virtues are no half so unquestionable as their Dearnesse. Whether the somewhat mysterious illness and death of the popes Leo IV and Paul II could have been caused by the great quantity of pearls and precious stones they were in the habit of wearing was a question seriously discussed by Johann Wolff, the supposed lethal effect being attributed to the coldness of such objects.[240] Indeed, the frigidity of precious stones was adduced by certain writers as one of the chief reasons for their remedial use in fevers.[241] Not only to King Frederick III of Denmark himself, to whom on his death-bed in 1670, a dose of pulverized bezoar was administered, but to his queen and their children such remedies were given, there being record that on September 19, 1663, a prescription containing red coral and pearl-powder was compounded by the Court Pharmacy for the queen, while a few years earlier the inevitable bezoar and also a tonic pearl-milk were administered to some of the royal offspring.[242] [Illustration: FAMOUS PEARL NECKLACE OF THE UNFORTUNATE EMPRESS CARLOTTA, WIDOW OF EMPEROR MAXIMILIAN OF MEXICO. ]