Many of the symptoms in the following list are more or less frequently, some of them invariably, present in the case of supposably healthy infants, and are commonly considered as entirely normal. Fairly considered, however, they are the effects of excess in diet. To the greatest possible extent the superfluous water contained in their gross diet passes off by the kidneys, causing immediately a diseased condition of those organs from overwork; the cellular tissue becomes loaded and distended with the fatty matters, and also with much water, unrecognized as dropsy until it reaches immense proportions; what really amounts to purging is so universal as to be regarded as the normal state of an infant’s bowels, and this is, sooner or later, often very early, succeeded by the reaction termed constipation. The back-aching that results from all this is none the less terrible because the little sufferers can not talk and tell where the pain is; peevishness, general _malaise_, and crying, tell of suffering, not of (their) perversity. Among the SYMPTOMS OF KIDNEY DISEASE are the following: frequent and copious micturition (wetting the bed or getting up at night); later the excretion of urine is scant, passed frequently, or, may be, suppressed altogether. Fat; later——emaciation. Heat and dull pain in the loins[48] (small of the back), increased by pressure; slight or considerable “puffing” about the eyes, noticeable only at times, or it may be constant and unrecognized as a symptom of disease; it may be diminished at times, as the secretion of urine becomes modified, or the condition of the system happens, temporarily, to improve. And it increases often when the secretion of urine diminishes, or is passed less freely. The countenance is more or less pallid, and may have a brownish tinge. Croupy breathing accompanies œdema of the larynx. “With children, inflammation of one or other of the organs of respiration is the most fatal tendency of the disease. Not only are they liable to pleurisy, pneumonia, and bronchitis, but, also, to membranous croup.” Constant tendency to irritability of manner, easily angered, unreasonableness, petulance; with infants——constant fretting, crying, nothing will interest or amuse them. [Footnote 48: Of all portions of the body, this should be lightly covered, never sweltered with wraps, bindings, or weight of garments.]