At the convention held in Philadelphia, 1833, to form the National Anti-Slavery Society, all the delegates were men, but a large number of women were present, and Lucretia Mott, who was a minister of the Friends' Society, and consequently was used to speaking to both sexes in Friends' meetings, spoke at the convention, but did not make any formal address. Several other women, also "Friends," spoke; and several years after, Samuel J. May, in speaking about it, said he was ashamed to say that though the convention passed a vote of thanks to the women for their interest, no one thought of asking any of them, not even Lucretia Mott or Mary Grew, to sign the "Declaration of Sentiments." I think the first women, undoubtedly, who addressed a _mixed_ audience of men and women of _all_ denominations were Angela Grimke, afterwards married to Theodore D. Weld, and her sister Sarah M. Grimke. Being Southerners, and having been slaveholders, being allied to the best families of Charleston, S. C., their knowledge was considered authentic, and a great interest was shown to hear them. They too began by addressing meetings of women, but when they spoke in Boston, in 1837, so great was the desire of the _men_ to hear them, that they were persuaded to hold public meetings of both sexes. I well remember the crowded audiences which listened to them with rapt attention. One can judge somewhat of the interest they excited from the fact that, at a time when no large halls or churches could be obtained for any kind of an Anti-Slavery meeting, the "Odeon," at the corner of Federal and Franklin Streets, then the largest and most popular hall in Boston, was obtained for a course of five lectures by these ladies, and was filled every evening by a dense crowd. Angelina was the finer speaker and gave three lectures out of the five. This was the only time the Odeon was ever opened to Anti-Slavery. They were members of the Friends' Society, which undoubtedly prevented them from embarrassment in addressing mixed audiences. Wendell Phillips says of them, "No man who remembers 1837 and its lowering clouds, will deny that there was hardly any contribution to the Anti-Slavery movement greater or more impressive than the crusade of these Grimke sisters from South Carolina, through the New England States." You see my answer to the question would be emphatically _Angelina and Sarah M. Grimke_. Very truly, SARAH H. SOUTHWICK. WELLESLEY, Mass. PUBLISHERS' DEPARTMENT.