The manuscript of the narrative which follows was placed in the hands of the compiler by a physician of Philadelphia who for many years had shown great kindness to its writer, in the endeavor to cure him of his pernicious habits. The writer seems from childhood to have been cursed with an excessive sensibility, and an unusual constitutional craving for excitement, coupled with an infirm and unreliable will. The habit of daily dependence upon alcohol appears to have been established for years before the use of opium was commenced; and the latter was begun chiefly for the purpose of substituting the excitement of the drug in place of the excitement furnished by brandy and wine. That any human being can permanently substitute the daily use of the one in place of the daily use of the other is more than doubtful. Attempts of this kind are not unfrequently made, but the result is uniformly the same--a double tyranny is established which no amount of resolution is sufficient to conquer. This fact is so forcibly illustrated in this autobiography, that although it is chiefly a story of suffering from the use of alcoholic stimulants, its insertion here may serve as a caution to that class of persons, not inconsiderable in number, who are tempted to substitute one ruinous habit in place of another. I am inclined to think I must have been born, if not literally with a propensity to _stimulus_, at least with a susceptibility to fall readily into the use of it; for my ancestors, so far as I know, all used alcohol, though none of them, I believe, died drunkards. One of my earliest recollections is that of seeing the tumbler of sling occasionally partaken of by the elders of the family, even before breakfast, and of myself with the other children being sometimes gratified with a spoonful of the beverage or the sugar at the bottom. Paregoric, too--combining two of the most dangerous of all substances, alcohol and opium--was a favorite medicine of my excellent mother, and in all the little ailments of childhood was freely administered. So highly thought she of it that on my leaving home at fifteen for Cambridge University she put a large vial of it in my trunk, with the injunction to take of it, if ever sick. In my young days I saw alcohol used everywhere. How in those days any body failed of the drunkard's grave seems hardly less than miraculous. How I myself escaped becoming inebriate for more than twenty-five years, is with my organization, a deep mystery. I can remember, when quite young, occasionally drinking--as I saw every body else do, boys as well as men, and even women--and I recollect also being two or three times overcome with liquor, to my infinite horror and shame not less than bodily suffering. At fifteen, as I said, I entered Harvard University, perfectly free from the _habit_ of drinking as from all other bad habits. Here too, as everywhere before, I saw alcohol flowing copiously, the most prevalent kind being wine.