The first symptoms attendant on breaking off the habit, coming on some hours after omitting the wonted dose, are a constant propensity to yawn, gape, and stretch, together with somewhat of languor, and a general uneasiness. Time passes, and there follows a sensation as if the stomach was drawn together or compressed, as if with a slight degree of cramp, coupled with a total extinction of appetite; the mouth and throat become dry and irritated; there is an incessant disposition to clear the throat by "hemming" and swallowing, and there is a tickling in the nose which necessitates frequent sneezing, sometimes a dozen or even twenty times in succession. As the hours go on, shudders run through the frame, with alternate fever heats and icy chills, hot sweats and cold clammy sweats, while a dull, incessant ache pervades the bones, especially at the joints, alternated by an occasional sharp, intolerable pang, like tic-douloureux. Then follow a host of indescribable sensations, as of burning, tinglings, and twitchings, seeming to run along just beneath the surface of the skin over the whole body, and so strange are these sensations that one is prompted to scream, and strike the wall, the bed, or himself, to vary them. By this time the liver commences a most energetic action, and a violent diarrhea sets in. The discharges are not watery or mucous, but, save in thinness, not very unlike healthy stools for the most part. Not long, however, after the commencement of the diarrhea, so copious is the effusion of bile from the liver, that one will sometimes pass, for a dozen stools in succession, what seems to be merely a blackish bile, without a particle of fæces mingled with it. But this lasts not many days, and is followed by the thin, not altogether unhealthy-looking discharges above mentioned, repeated often an incredible number of times per day. Whether from the quality of these discharges, or from whatever cause, the interior surface of the bowels feels intolerably hot, as though excoriated, and it seems as if boiling water or aqua fortis running through the intestines would scarce torture one more than these stools. In fact, all the internal surfaces of the body are in this same burning, raw-feeling state. The brain, too, is in a highly excited, irritable condition; the head sometimes aching and throbbing, as though it must burst into fragments, and a humming, washing, simmering noise going on incessantly for days together. Of course there can be no sleep, and one will go on for ten days and nights consecutively without one moment's loss of intensest consciousness, so far as he can judge! Strange to say, notwithstanding this excessive irritation of the entire system, one feels so feeble and strengthless that he can scarce drag one foot after the other, and to walk a few rods, or up a flight of stairs, is so terribly fatiguing that one must needs sit down and pant. (Let it be noted, that these symptoms belong to the case where