"During the early months of the year 1803, the pain in Mr. Hall's back increased both in intenseness and continuity, depriving him almost always of refreshing sleep, and depressing his spirits to an unusual degree. "Often has he been known to sit close at his reading, or yet more intently engaged in abstract thought, for more than twelve hours in the day; so that when his friends have called upon him, in the hope of drawing him from his solitude, they have found him in such a state of nervous excitement as led them to unite their efforts in persuading him to take some mild narcotic and retire to rest. The painful result may be anticipated. This noble mind lost its equilibrium. "Throughout the whole of Mr. Hall's residence at Leicester, he suffered much from his constitutional complaint; and neither his habit of smoking nor that of taking laudanum seemed effectually to alleviate his sufferings. It was truly surprising that this constant, severe pain, and the means adopted to mitigate it, did not in any measure diminish his mental energy. "In 1812 he took from fifty to one hundred drops every night. Before 1826 the quantity had increased to one thousand drops. "Mr. Hall commonly retired to rest a little before eleven o'clock; but after his first sleep, which lasted about two hours, he quitted his bed to obtain an easier position on the floor or upon three chairs, and would then employ himself in reading the book on which he had been engaged during the day. Sometimes, indeed often, the laudanum, large as the doses had become, did not sufficiently neutralize his pain to remove the necessity for again quitting his bed. For more than twenty years he had not been able to pass a whole night in bed. When this is borne in mind it is truly surprising that he wrote and published so much; nay, that he did not sink into dotage before he was fifty years of age. "Early on the Sunday morning (Mr. Addington says) being requested to see him, I found him in a condition of extreme suffering and distress. The pain in his back had been uncommonly severe during the whole night, and compelled him to multiply at very short intervals the doses of his anodyne, until he had taken no less than 125 grains of solid opium, equal to more than 3000 drops, or nearly four ounces of laudanum!! This was the only instance in which I had ever seen him at all overcome by the soporific quality of the medicine; and it was even then hard to determine whether the effect was owing so much to the quantity administered as to the unusual circumstance of its not having proved, even for a short time, an effectual antagonist to the pain it was expected to relieve.