serves as a striking monument of the appalling and wide-spread destruction to which it is the sole and conspicuous exception. WHAT SHALL THEY DO TO BE SAVED? Most of the preceding pages were already prepared for the press, when the attention of the compiler was attracted by a very remarkable article in _Harper's Magazine_ for August, 1867, entitled, "What Shall They Do to be Saved?" The graphic vividness of the story, as well as the profound insight and wide experience with which it was written, led me to solicit from the unknown author the addition of it to the pages of my own book. It proved to be from the pen of Fitz Hugh Ludlow, already recognized by the public as a writer of eminence, both in science and letters. The permission being freely accorded, I was still further moved to ask that he would give me a statement of the method pursued by him in dealing with the class to which it refers. The letter following his article was his response to my request. It will be seen to contain an outline of his views upon the subject to which he has devoted some years of study and practice, and is especially valuable as embodying the germ of a plan by which, according to his growing conviction, the opium-eater can alone be saved. As the conclusions of a writer who seems to the compiler to be singularly intelligent and definite in his knowledge of this most interesting and difficult field of disease and treatment, it needs no further recommendation to the attention of the reader. Since the publication of his August article, a multitude of letters received from all portions of the country, asking his advice and assistance in such cases as this book describes, has left a profound conviction upon his mind of the most crying need of the establishment of an institution where opium-eaters can be treated specially. In this view of the urgent necessities of the case, the compiler most heartily and earnestly concurs. * * * * * I have just returned from forty-eight hours' friendly and professional attendance at a bedside where I would fain place every young person in this country for a single hour before the Responsibilities of Life have become the sentinels and Habit the jailer of his Will.