Accordingly, without much more instinct of concealment than if it were an occasional tendency to some slight convivial excess, he had resort to M'Munn, in ounce doses, whenever the world went wrong with him. If he had a headache or a toothache; if the weather depressed him; if he had a certain "stint" of work to do without the sense of native vigor to accomplish it; if he was perplexed and wished to clear his head of passion; if anxieties kept him awake; if irregularities disturbed his digestion--he had always one refuge certain. No fateful contingency could pursue him inside M'Munn's enchanted circle. He was a young and wealthy bachelor, living the life of a refined _bon vivant;_ an insatiable traveller, surrounded by flatterers, and without a single friend who loved him enough to warn him of his danger excepting those who, like himself, were too ignorant to know it. After three years of dalliance he became an habitual user of opium, and had been one for eight years when I was first called to him. By the time that the daily habit fastened itself he had learned of other opiate preparations than M'Munn's, and finding a certain insufficiency characterize that tincture as he increased the size of the dose, had recourse to laudanum, which contains the full native vigor of the drug unmodified. This nauseated him. He had the same experience with gum opium, opium pills, and opium powder; so that he was driven to that form of exhibition which sooner or later naturally strikes almost every opium-eater as the most portable, energetic, and instantaneous--morphia or one of its salts. My friend usually kept the simple alkaloid in a paper, and dissolved it as he needed it in clear water, sometimes substituting an equivalent of "_Magendie's Solution_," which contains sixteen grains of the salt diffused through an ounce of water by the addition of a few drops of sulphuric acid. When I first saw him he had reached a daily dose of twelve grains of sulphate of morphia, and on occasions of high excitement had increased his dose without exaggerating the sensible effect to nearly twenty. The twelve which formed his habitual _per diem_ were divided into two equal doses, one taken immediately after rising, the other just about sundown.