This ingenuity manifests itself in subterfuges of a complicated construction and artistic plausibility which might have puzzled Richelieu; but it is really nothing to wonder at when we recollect the law of nature by which any extreme agony, so long as it continues remediable, sharpens and concentrates all a man's faculties upon the one single object of procuring the remedy. If my house is on fire, I run to the hydrant by a mere automatic operation of my nerves. If my leg is caught in the bight of a paying-out hawser, my whole brain focuses at once on that single thought, "_an axe."_ If I am enduring the agony which opium alone can cause and cure, every faculty of my mind is called to the aid of the tortured body which wants it. When a man has used opium for a long time the condition of brain supervening on his deprivation of the drug for a period of twenty-four hours is such as very frequently to render him suicidal. Cottle tells us how Coleridge one day took a walk along Bristol wharves, and sent his attendent down the pier to inquire the name of a vessel, while he slipped into a druggist's on the quay and bought a quart of laudanum; but in no fibre of his nature could Cottle conceive the awful sense of a force despotizing it over his will, a degradation descending on his manhood, which Coleridge felt as he concentrated on that one single cry of his animal nature and the laudanum which it spoke for, all the faculties of construction and insight which had created the "Ancient Mariner" and the "Aids to Reflection."