The opium-eater now only continues his habit to preserve the terrible static condition to which it has reduced him, and to prevent that yet more terrible dynamic condition into which he comes with every disturbance of equilibrium; a condition of energetic and agonizing dissolutions which must last until every fibre of wrongly-changed tissue is burned up and healthily replaced. Though I have called the early reactions of opium rapid, they are necessarily much less so than those produced by a simple chemical agent. No drug approaches it in the possession of _cumulative_ characteristics; its dependence on the time element must therefore be always carefully considered in treating a case. This fact leads us to understand the other element in the question, how long the torments of the opium-fighter must continue. Having ascertained the chronology of his case, we must say, "Given this period of subjection, has the patient enough constitutional vigor left to endure the period of reconstruction which must correspond to it?" [Footnote: Not correspond day by day. At that rate a reforming opium-eater (I use the principle in the _physical_ sense, for very few opium-eaters are more to blame than any other sick persons) must pay a "shent per shent" which no constitution could survive. The correspondence is simply proportional.] I am naturally sanguine, and began my study of opium-eaters with the belief that none of them were hopeless. Experience has taught me that there is a point beyond which any constitution--especially one so abnormally sensitive as the opium-eater's--can not endure keen physical suffering without death from spinal exhaustion. I once heard the eminent Dr. Stevens say that he made it a rule never to attempt a surgical operation if it must consume more than an hour. Similarly, I have come to the conclusion never to amputate a man from his opium-self if the agony must last longer than three months. Uneasiness, corresponding to the irritations of dressing a stump--may continue a year longer; a few victims of the habit outlive a certain opium-prurience, which has also its analogue in the occasional titillation of a healed wound--these are comparatively tolerable; but, if we expect to save a patient's life, we must not protract an agony which so absolutely interferes with normal sleep as that of the opium-eater's for longer than three months in the case of any constitution I have thus far encountered.