I have thus given as clear an outline as I can of my idea what such an institution as we have so often talked over ought to be, and described a method of treatment which has been successful wherever I have had the opportunity even to approach its realization. For its perfect realization an institution especially devoted to the noble work is a _sine qua non_. If the publication of this letter shall call to our aid in its establishment, by awakening to a sense of its necessity, any of our vigorous, public-spirited countrymen, I am sure we may live to see it flourishing on a sound basis and doing an incalculable amount of good which shall make mankind wonder how so many generations ever lived without it since opium began to scourge the world. I shall then, too, be even more indebted to you than I am now for the courtesy which has afforded so large a space in your book to Your Friend, FITZ HUGH LUDLOW.