"I was ill at that time and for years after--ill from the effects of opium upon the liver, and one primary indication of any illness felt in that organ is peculiar depression of spirits. Hence arose a singular effect of reciprocal action in maintaining a state of dejection. From the original physical depression caused by the derangement of the liver arose a sympathetic depression of the mind, disposing me to believe that I never _could_ extricate myself; and from this belief arose, by reaction, a thousand-fold increase of the physical depression. I began to view my unhappy London life--a life of literary toils odious to my heart--as a permanent state of exile from my Westmoreland home. My three eldest children, at that time in the most interesting stages of childhood and infancy, were in Westmoreland, and so powerful was my feeling (derived merely from a deranged liver) of some long, never-ending separation from my family, that at length, in pure weakness of mind, I was obliged to relinquish my daily walks in Hyde Park and Kensington Gardens from the misery of seeing children in multitudes that too forcibly recalled my own. "Meantime it is very true that the labors I had to face would not even to myself, in a state of good bodily health, have appeared alarming. _Myself_, I say, for in any state of health I do not write with rapidity. Under the influence, however, of opium, when it reaches its maximum in diseasing the liver and deranging the digestive functions, all exertion whatever is revolting in excess. Intellectual exertion above all is connected habitually, when performed under opium influence, with a sense of disgust the most profound for the subject (no matter what) which detains the thoughts; all that morning freshness of animal spirits, which under ordinary circumstances consumes, as it were, and swallows up the interval between one's self and one's distant object, all that dewy freshness is exhaled and burned off by the parching effects of opium on the animal economy.