[136] Driesch, H., _Science and Philosophy of the Organism_, i., p. 104. [137] Herbst, C., _Formative Reize in der tierischen Ontogenese_. Leipzig, 1901. 6. As a consequence of further changes definite anlagen or buds originate later in the embryo which are destined to give rise to definite organs. Thus in the tadpole early mesenchyme cells are formed which are the anlagen for the four legs, which will grow out under the proper conditions. These anlagen are specific inasmuch as from the anlage of a foreleg only a foreleg, and from the anlage for a hindleg only a hindleg, will develop. Braus[138] has proved this by transplanting the anlage of a foreleg to different parts of the body. No matter into which part of the body they are transplanted the mesenchyme cells for the foreleg will give rise to a foreleg only; even if they are transplanted into the spot from which the hindlegs grow out under natural conditions. There is therefore nothing to indicate “regulation.” [138] Braus, H., _Münchener Med. Wochnschr._, 1903, 1 (II.), No. 47, p. 2076. The same is true for the formation of the eye and probably in general. We have to consider the formation of the various organs of the body as being due to the development of specific cells in definite locations in the organisms which will grow out into definite organs no matter into which part of the organism they are transplanted. It is at present unknown what determines the formation of these specific anlagen. They may lie dormant for a long time and then begin to grow at definite periods of development. We shall see later that we know more about the conditions which cause them to grow.