740. But the microscope, by bringing the successive development of the compound gland in the embryo of the higher animal under the cognizance of sense, perfectly discloses the nature of its composition. In the development of the incubated egg every step of the progressive formation of the compound gland is rendered visible to the eye. When this process is carefully watched, it is seen that the part of the gland first formed is the excretory duct, which springs from the blastema, the common mass of matter out of which all the organs are formed. From this duct the elementary parts of the gland bud just as bunches of grapes bud from the stalk. The buds, at first at considerable distances from each other, approach nearer as they increase by new growths, until at length they come into actual contact. The growth continuing, and the compactness of the substance of the gland proportionally increasing, the primitive form of the elementary bodies which compose it is ultimately lost. The substance of the gland now appears to consist of compact solid matter, which is commonly termed parenchyma. The component particles of this parenchymatous and apparently solid substance present a clustered or grape-like appearance, from which they early obtained the name of acini, from the Latin word acinus, a berry. This term, originally employed merely to express the clustered and branching appearance of the elementary parts of the gland, has since been used in widely different senses. By some it has been employed to express solid glandular grains constituting a supposed distinct parenchymatous substance, differing in every different gland. It is now proved that no such solid granular particles enter into the composition of any gland in the animal kingdom. By others the term acini has been employed to express granular bodies composed of blood-vessels, directly continuous with the excretory ducts, and from which the excretory ducts derive their origin. Recent investigation has demonstrated that there is no continuity of the blood-vessels into the excretory duct either in the acini or in any other part of the gland. It is established that the blood-vessels are spread out upon the walls of the secreting canals and do not form with them continuous tubes. The bodies which have been mistaken for granular particles, constituting the so called solid acini, are really the shut extremities of hollow follicles, cæca, or tubuli, which appear solid only from the closeness with which they are compacted. When carefully dissected and examined under the microscope, their real nature becomes apparent, and this is also sometimes capable of being demonstrated by injection; for some of these elementary bodies are vesicular, and can be filled with mercury, when they present a beautiful appearance like clusters of diamonds; or they may be inflated with air, just as the air vesicles of the lungs. [Illustration: Fig. CXCI.