Section_ contains: Arguments proving that in most parts of Europe the Venereal Disease became known and disseminated since 1493, and last of all in the month of June 1495. pp. 1-10.—_Second Section_: When did Christopher Columbus discover the Island of Hispaniola and when did he return to Spain from his first and second voyages? pp. 11-20.—_Third Section_: Did the Venereal Disease come from America at the time of Columbus’ return from his second voyage? pp. 21-39.—_Fourth Section_: Did the Troops of Fernandez Cordova communicate the Disease to the French? pp. 40-47.—_Fifth Section_: Answer to some objections that may be raised to prove that Venereal Disease took its origin from America, pp. 47-79.—_Sixth Section_: Reasons which caused Writers on Venereal Disease since the year 1517 to believe this Malady came from America, pp. 79-87.—_Seventh Section_: Venereal Disease is an Epidemic Complaint, which began in Italy and almost at the same time spread over France and the rest of Europe, pp. 88-108.—_Recapitulation_: The Disease existed in Italy and France before Columbus returned from his second Voyage; the Troops of Cordova could not have communicated it to the French, for the two never came into contact; the Disease displayed all the appearance of an Epidemic; the discovery of the drug “Guajac” gave occasion to the assumption of the American origin of the Disease.—_Van Swieten_, who had received the English Translation sent to him by Castro, only ought to weaken the proofs brought forward in this book in his “Commentar. in Boerhavi Aphorismos” (Commentary on Boerhaave’s Aphorisms), Leyden 1772., Vol. V. pp. 373 sqq., which occasioned _Sanchez_ to issue the following Work, also published anonymously. 5) Examen historique sur l’apparition de la maladie vénérienne en Europe, et sur la nature de cette epidémie. A Lisbonne MDCCLXXIV. pp. VIII. and 83. 8vo. (“Historical Inquiry concerning the First Appearance of the Venereal Disease in Europe, and the Nature of that Epidemic.” Lisbon 1774. pp. VIII, and 83. 8vo.).