Just about the beginning of the fourteenth century {223} Pope Boniface VIII., who was himself one of the distinguished scholars of his time, determined that, besides the university of the Papal Court, which had existed for nearly a century at Rome, but which was mainly occupied with philosophy and theology and mainly attended by ecclesiastics, there should also be a university of the City of Rome for the people of his capital. This determination was reached only a short time before the culmination of the difficulty between Pope Boniface and the King of France, which eventually resulted in what has been called the outrage of Anagni and the subsequent death of the Pope within a short time. It has usually been thought, then, that in spite of certain extant Papal documents creating the University of the City of Rome, this university had not been organized before Pope Boniface's death, and as his successor did not take his seat at Rome, but at Avignon, it has usually been assumed that the University of the City came into existence at most only in an abortive form. Denifle, whose History of the Universities of the Middle Ages is looked upon as the best authority in such matters, however, insists that a complete university of the City of Rome did come into existence as a result of Boniface's decree. All during the time when the Popes were at Avignon this university continued to exist, and in spite of the fact that at one time, as a consequence of a great earthquake followed by a pestilence, and then serious political troubles because of the absence of the Popes, Rome had only something less than ten thousand inhabitants, the university continued its work. Denifle calls attention to the fact that there are letters of Pope John XXII. which show that he paid out of the Papal revenues {224} the salary of a teacher of physic at the University of the City of Rome while the Papal Court was at Avignon. It is rather interesting to find the names of the two Popes, Boniface VIII. and John XXII., whose Papal decrees are supposed to have prevented the study of anatomy and chemistry, thus cropping up on unquestionable authority as the founder and the patron of medical teaching in the City of Rome. Pope Boniface VIII. is now generally credited with having been the founder of the Sapienza, the medical school of which, at the beginning of the sixteenth century, was to develop into one of the most important schools of its kind in Europe, and to have on its faculty list the greatest teachers of their time, who had been tempted to come to Rome because the Popes wished to enhance the prestige of the medical school of their capital.