How well the Popes were justified in their estimation of Columbus's genius as an anatomical investigator will be best appreciated from his discovery of the pulmonary circulation, which formed, as Harvey confesses at the beginning of his work on the circulation, the foundation on which Harvey's great discovery naturally arose. It is probable that Columbus would not have come to Rome, in spite of the flattering offers held out to him, only that he was already the personal friend of a number of high ecclesiastics, and even of the Pope who extended the invitation. How well the Popes continued to think of Columbus after his years of work in the {235} Roman Medical School will be well understood from the fact that, when his great work _De Re Anatomica_ was published after his death by his sons, Pope Pius IV. accepted the dedication of it. This was of course not an unusual thing, for many books on other sciences were dedicated to the Popes, and the example thus set was subsequently imitated. Twenty-five years later, Professor Piccolomini dedicated his Anatomical Lectures to Pope Sixtus V. Subsequent anatomical publications of the Papal Medical School were issued under like patronage. The famous edition of Eustachius's anatomical sketches, published under the editorship of Lancisi, is a notable example of this, and went to press mainly at the expense of Pope Clement XI., who realized how valuable they were likely to be for the teaching of anatomy. These two great discoverers in anatomy, Columbus and Eustachius, were succeeded, as is so often the case in the history of university faculties, by a man more capable of writing about great discoveries than of making them himself. This was Piccolomini, who devoted himself to showing how much the ancients had taught about anatomy, though at the same time he also made clear the place occupied by modern anatomical discoveries. While his name is not attached to any great discovery in the science of anatomy, he is generally acknowledged to have been one of the great teachers of his time and one who was needed just then in order to make people realize how the old and the new in anatomy must be coordinated. Piccolomini's successor in the chair of anatomy at Rome was another original genius and investigator whose name, however, and fame has never been as great among English-speaking people as in Italy, or among the Latin races generally. The fact that he was a rival {236} of Harvey's in the matter of the discovery of the circulation of the blood has always made the Italians exaggerate his position in medical history, while it has undoubtedly made English writers of medical history diminish the importance of his work.