Pope Innocent III. was not the only occupant of the Papal throne whose name deserves to be remembered with benedictions in connection with the hospital movement of the thirteenth century. His successor took up the work of encouragement where Innocent had left it at his death, and did much to bring about the successful accomplishment of his intentions in the ever wider spheres. Honorius III. is distinguished by having made into an order the Antonine Congregation of Vienna, which was especially devoted to the care of patients suffering from the "holy fire" and from various mutilations. The disease known as the holy fire seems to have been what is called in modern times erysipelas. During the Middle Ages it received various titles, such as St. Anthony's fire, St. Francis's fire, and the like, the latter part of the designation evidently being due to the striking redness which characterizes the disease, and which can be compared to nothing better than the intense erythema consequent upon a rather severe burn. This affection was much more common in the Middle Ages than in later times, though it must not be forgotten that its {277} disappearance has come mainly in the last twenty-five years. It is now known to be a contagious disease, and indeed, as Oliver Wendell Holmes pointed out over half a century ago, may readily be carried from place to place by the physician in attendance. It does not always manifest itself as erysipelas when thus carried, however, and the merit of Dr. Holmes's work was in pointing out the fact that physicians who attended patients suffering from erysipelas and then waited on obstetrical cases, were especially likely to carry the affection, which manifested itself as puerperal fever. A number of cases of this kind were reported and discussed by him, and there is no doubt that his warning served to save many precious lives. Of course nothing of this was known in the thirteenth century; yet the encouragement given to this religious order which devoted itself practically exclusively to the care in special hospitals of erysipelas, must have had no little effect in bringing about a limitation of the spread of the disease. In such hospitals patients were not likely to come in contact with many persons, and consequently the contagion-radius of the disease was limited. In our own time, immediate segregation of cases when discovered has practically eradicated it, so that many a young physician, even though ten years in practice, has never seen a case of it. It was so common during the Civil War and for half a century before that here in America, that there were frequent epidemics of it in hospitals, and it was generally recognized that the disease was so contagious, that when it once gained a foothold in a hospital ward nearly every patient suffering from an open wound was likely to be affected by it.