the putrid contents of their own intestines which found a way out through the ruptured appendix. These cases were set down as poisoning cases, and usually some interested person was the subject of suspicion. Dr. Phreas's learning had obtained for him an appointment to a bishopric in England, a curious bit of evidence of the absence of opposition between medical science and religion in his time. He died shortly after this, under circumstances that raised a suspicion of poisoning in the minds of some of his contemporaries--but raises the thought of appendicitis in mine,--and one of his rivals was blamed for it. [Footnote 12: Like the other distinguished physicians of this time, John Phreas did not devote himself to medicine alone. He had a taste for literature, and besides being an accomplished scholar he was a poet.] Nor did the custom for English medical students to go down to Italy to complete their education cease with the so-called reformation. Some two generations after Vesalius's time another distinguished Englishman, Harvey, went down to Italy to complete the studies he had already made and eventually to lay the foundation of that knowledge on which he was twenty years later to construct his doctrine of the circulation of the blood. This doctrine, however, remained merely a theory until the distinguished Italian anatomist, Malpighi, after another half century, demonstrated the existence of the capillaries, the little blood vessels which connect the veins and arteries, and by thus showing the continuity of both the blood systems, proved beyond all doubt the certainty of the teaching that the blood does circulate. Students came, moreover, from even the distant North of Europe to the Italian schools of medicine during these centuries. Neil Stensen, or as he is perhaps better known by his Latin name, Nicholas Steno, the {97} discoverer of the duct of the parotid gland, which has been named after him, and of many other anatomical details, especially of the fact that the heart is a muscle, which stamp him as an original investigator of the highest order, after having made extensive studies in the Netherlands and in France to complete the medical education which he had begun in his native city of Copenhagen, went down into Italy to secure freer opportunities for original research than he could obtain anywhere else in Europe. [Footnote 13]