As the different stages of the disease are advancing, corresponding changes are taking place in the constitution of the patient; the heat and thirst increase, the pain, restlessness, and anxiety are augmented; the inflammatory and febrile actions keep advancing, rendering the slightest noise intolerable, and causing delirium and a chain of the most dangerous symptoms. _Treatment._—The inflammatory nature of small-pox renders what is called the cooling mode of treatment, in all its details, a duty of imperative importance. For this purpose, the room in which the patient is placed should during the disease be kept dark and cool, and at least once a day thoroughly ventilated by means of a fire in the grate, for a short time night and morning, but especially at the latter period. The room, also, should be frequently purified by sprinkling the floor with chloride of lime, or by the burning of vinegar on a heated shovel. As the stomach is the first organ sensibly affected, and continues more or less disturbed during the whole disease, the treatment should begin by giving the patient an emetic, composed, if an adult, of twenty grains of ipecacuanha and one grain of tartar emetic; and as soon as that operation has ceased, the following powders and saline purgatives are to be employed, giving the mixture every _two_, and the powders every _four hours_. Take of Epsom Salts 1 ounce. Mint Water 8 ounces. Antimonial Wine 3 drachms. Spirits of Nitre 2 drachms. Syrup of Saffron 2 drachms. Mix, and give to an adult two table-spoonfuls for a dose, and to children, according to their age, from a dessert-spoonful upwards. Take of Calomel 3 grains. Powdered Antimony 2 grains. Rhubarb 3 grains. Jalap 10 grains. Mix, and make a powder. Give _one_ of such a strength, every _four hours_ to an adult till the bowels are _well_ acted on, when they are to be discontinued; but the mixture is to be persisted in, though less frequently, or in half the dose. For a child from nine to twelve years of age, _half_ of one of the above powders is to be given every _four hours_, till the same result is effected; and for younger children, each powder of the above strength is to be divided into _three parts_, and administered as the others. For an ordinary drink, in which the patient should on no account be stinted, lemonade, thin gruel, or cold tea is to be used; all solid food or nutritious aliment must be withheld, the patient kept low, his head cool, and the feet hot.