After twelve hours, and between that and two days, the _second stage_, or series of symptoms sets in, the headache and wild delirium cease, and are succeeded by a low indistinct muttering and a state of stupor, from which it is finally impossible to rouse the patient. Hearing and vision become imperfect and difficult, with squinting, double vision, and distended immovable pupil: the spasms have given place to twitching of the muscles, and starting of the tendons: the limbs are cold and powerless, or palsied, the countenance ghastly; a cold sweat breaks out over the body, and the patient dies in a state of profound coma. _The treatment in this second_ and fatal stage, is necessarily one more of regimen than medicine. If the pulse is hard, a blister may be put on the head; but the great art lies in the judicious application of stimulants, such as ether, ammonia, valerian, beef tea, wine, and opiates. The following mixture combines most of these agents, and may be employed to promote reaction, accompanied with thickened beef tea, and bottles of hot water to the feet. Carbonate of Ammonia ½ drachm. Powdered Opium 3 grains. Ipecacuanha 3 grains. Mix in a mortar, and add Camphor Water 5½ ounces. Compound Tincture of Cinnamon ½ ounce. Sulphuric Ether 1 drachm. Mix. A table-spoonful every two hours. DELIRIUM. A symptom of some form of disease, as of madness, inflammation of the substance of the brain, or of its coats, of fevers, erysipelas, disease of the bladder; or it may supervene after concussion or compression of the brain, injuries of the head, the result of surgical operations, or from many vegetable poisons. Delirium, though often the result of an excess of blood in the head, is by no means invariably so, as delirium frequently attends as a reactionary symptom after exhaustion; and from nervous irritation. There are many varieties of this distressing symptom, as the low muttering delirium of typhus fever, and the quick rambling chattering of other forms of cerebral disturbance. Delirium is generally attended with a quick jerking pulse, the face is flushed, the eyes red or bloodshot, with pain in the head, ringing in the ears, great antipathies to places, persons, or things, muscular exertions of the arms, or picking at the bed-clothes, constant and incoherent talk, or low indistinct muttering. The body is often hot and dry, and the feet cold; and in cases of vegetable poisoning, the pupils are generally excessively dilated.