Each paroxysm of an intermittent fever is divided into three different stages, which are called the cold, the hot, and the moist stage. The cold stage commences with languor, a sense of great debility, frequent yawning and stretching, and an aversion to food. The face and extremities become pale, the features shrink, the bulk of every external part becomes diminished, the nails turn a dark blue colour, and the skin, over the whole body, bears the appearance of having been exposed to excessive cold: at this time, universal rigours come on, together with pains in the head, back, loins, and joints, nausea and vomiting of bilious matter; the breathing is small, frequent, and anxious; the urine is almost colourless; the thoughts are confused; and the pulse is small, frequent, and often irregular. After a short time, these symptoms abate, and the second stage commences with an increase of heat over the whole body, redness of the face, dryness of the skin, thirst, pain in the head, throbbing in the temples, anxiety and restlessness; the respiration (breathing) is fuller and more free, but still frequent; the tongue is furred, and the pulse has become regular, hard, and full. If the attack has been very severe, delirium will perhaps arise at this time. After these symptoms have continued for some time, a moisture breaks out on the forehead, and, by degrees, becomes a profuse perspiration, extending over the whole body. Having pointed out the phenomena usually attending a paroxysm of intermittent fever, and likewise their mode of succession, it may be as well to observe, that they prevail in different degrees of intensity, and that the series of them may be more or less complete. The treatment of intermittents is, first, to put as speedy a stop to the fit as possible when it has taken place; and, secondly, to prevent its return at the usual, or any after period. Two drachms of Peruvian bark, powdered, may be taken every two hours, as the benefit to be expected from this medicine will greatly depend on the large quantity administered in a short space of time; for, five or six ounces of bark taken in a few days, will be attended with a much better effect than perhaps as many pounds taken in the course of some weeks. In instances where bark fails of remaining on the stomach (as in the writer’s case), arsenic is almost invariably successful: it must be prepared as follows:—