Our experience shows that many cases have auto-intoxication of gastro-intestinal origin. The hospital care of such cases makes possible the thorough cleansing of the colon by irrigation and the reestablishment of an acid producing flora which seems to prevent fermentation. =Osteopathic Corrective Work.=—Thoroughness of treatment for the removal of all causes is the secret of success. To successfully remove the immediate sources of auto-intoxication by treating a sinus infection or by thoroughly freeing the colon from fermentation products means only temporary results if the underlying causes are not corrected. A thorough osteopathic examination is necessary to determine such causes and certainly such treatment should not be neglected. Correction of all cervical and upper thoracic lesions and particularly the clavicles and ribs is important. These lesions seem to be the result rather than the cause, but normal respiratory functions seemingly cannot be maintained unless such treatment is done. Sinuitis Acute or chronic inflammatory disease of the nasal accessory sinuses with or without suppuration is more common, I believe, and is responsible for more complications and chronic affections of the nose and throat than is generally known. =Etiology.=—The cause in most cases lies in unsuccessfully treated acute infections involving the nose and throat. Abnormalities of the nasal respiratory passages such as deflected septum, enlarged or cellular turbinates, adhesions resulting from cautery or careless surgery, causing deficient drainage, constitute the local causes. Underlying some of these direct causes, lesions of the cervical region which impair the nutrition to and drainage from the head are to be considered. =Symptoms and Diagnosis.=—Acute or chronic headaches and neuralgic pains of the head are common symptoms. Acute sinuitis of the frontal sinuses is accompanied by marked and persistent frontal headache and pain in the eyes. In infections of the maxillary sinus there is usually pain over the affected part, but there is often referred pain to other parts of the head. Sphenoidal sinuitis usually causes general headache with no definite location. By direct examination of the nasal cavities a purulent or mucopurulent discharge may be seen and the source determined. In many cases, however, the pus may be retained or insufficient in amount to detect by direct examination. Transillumination in a dark room by means of a good transilluminator will usually show a darkened area over the affected part. The average battery equipments commonly sold for this purpose are of little value. The X-ray plate when properly done, is more dependable than the transilluminator.