=Treatment.=—Of the etiologic factors above mentioned, that of auto-intoxication, resulting possibly from endocrine disturbances or other sources, is most generally accepted in the medical world and agrees excellently with the osteopathic point of view. Spinal lesions are regularly found more particularly in the dorsal region, which are quite capable of disturbing the innervation to the glands; therefore, their nutrition and activity. A correction of these before the disturbance has continued too long, and hence before deterioration has set in, should theoretically normalize the glandular condition and therefore prevent deterioration and enable the patient to recover. Such is the probable explanation of the results, and in many cases the recoveries were obtained in patients previously considered hopeless. Remarks by Dr. Hildreth In a great majority of the cases the cause lies in the interference between the fourth dorsal vertebra and the eighth, which analyzed means a disturbance of the great splanchnic nerves, through whose interference would be caused the toxic condition and even the sexual disturbance described in so many cases from standard authorities. The same lesion, if deep seated enough, could produce an interference with the vasomotors and reflexly interfere with the circulation to the brain. In many we also find a first, second or third cervical lesion. The effects of these lesions on the equilibrium of the circulation to the brain are easily traced through the superior cervical sympathetic ganglia. These lesions, namely, the mid-dorsal and upper cervical, especially when corrected in the earlier stages, have thus far proven to produce successful results. In a lesser number of cases we find the cause to be from the first to the fourth dorsal vertebræ; our reasoning here being that the interference or the physical disturbance must be so deep that it reaches and interferes with the deeper nerve currents, both downward and upward, thus disturbing the equilibrium of the circulation to the brain. We have found this class to be the hardest to respond to treatment; however, that may be due to the fact that the physical defects at that point are harder to correct. Osteopathic treatment applied to the lesions above described without question offers therapeutics of intrinsic value to this class of patients. Delirium, Confusion and Stupor