An even more positive contra-indication to chloroform is found by Gosselin in the case of stupor following severe wounds. No one will dispute that narcotisation is at first entirely out of the question; it only remains doubtful for how long a time after the injury it is unsafe to give chloroform for operative purposes. Gosselin is for total exclusion, since even after the apparent departure of stupor, a kind of concealed shock to the system may still exist, and would render anæsthesia dangerous. He also thinks that in recent dislocations, especially of the shoulder, chloroform is not only usually needless, but contra-indicated by the fact that the patient’s want of sensibility may permit such force to be used as may inflict severe injuries upon the nerve trunks; and even in old dislocations chloroform should not be used till other means have been tried. This contra-indication, also, is opposed by Nagel, who brings a large amount of experience to controvert it; it even happens, sometimes, that the muscular tone can be sufficiently relaxed for the reduction without any loss of consciousness. The chief contra-indication to chloroformisation which Nagel admits is the pre-occurrence of long-standing or considerable (arterial) hæmorrhage, and advanced age, especially if there be also heart or lung disease, vascular degeneration, emphysema, &c., also the fact that the operation might cause blood to enter the larynx; and in hernia, because of the tendency to vomit. He recommends the greatest care in giving it to refractory patients, who struggle, scream, and hold their breath. The danger of asphyxia increases every moment, and it is necessary to have ready the means of throwing in a stream of pure air or of oxygen, through the _nose_, sprinkling the patient with cold water at the same time. Nagel has also observed that the restlessness and oppression produced by half-felt pain in incomplete narcosis, and the consequently insufficient respirations, may produce an even fatal exhaustion. Narcosis should therefore be properly kept up as long as it is wanted. (_Der Praktische Arzt._)