[It is very necessary that we should study the opinions of foreign physicians and surgeons as to the dangers of anæsthesia. At the same time, I think it right to protest here that the cautions given even by Nagel, and still more those which Gosselin inculcates (with two exceptions), are to me inexplicable. At least they can only be understood upon the supposition that the means of inducing anæsthesia which are employed by these authorities are extremely inefficient and improper. A former very large experience of chloroform administration, some years ago, impressed me with the confident belief that if chloroform be given with proper care and with a Snow’s, or still better a Clover’s apparatus, there is really no danger whatever in its use, except in two cases—that of shock after severe injury, and that of delirium tremens. I cannot admit that a patient who is in a fit condition to undergo a surgical operation at all is placed in any worse position for supporting the shock of it by the fact that he has been chloroformised, if this has been skilfully done—the case of severe shock from injury always excepted.—F. E. ANSTIE.] =Subcutaneous Injection of Mercury in Syphilis.=—Dr. A. Stöhr records a series of clinical observations on this method of treatment, which are very interesting. He considers that the subcutaneous injection of the bichloride is the most effective and direct means of producing the curative effects of mercury which has ever been applied. Stöhr employed the treatment for 96 patients; in almost all the cases it was carefully ascertained that no specific treatment had been previously adopted. His cases included a larger relative proportion of inveterate syphilis than those treated by Lewin in his researches, described by M. Bricheteau in the _Practitioner_ for March. Stöhr considers that the hypodermic method is not needed for the milder forms of syphilis. Old and obstinate cases, on the other hand, in which inunction or other forms of mercurialisation have been vainly tried, are particularly appropriate for a trial of the subcutaneous method. It is especially indicated in such cases as those of iritis and of dangerous laryngeal affections, in which it is important to produce a very rapid effect; also in severe and extensive syphilitic skin affections, in which inunction cannot be applied. Syphilis of the bones and periosteum, and syphilitic gummata, are but little influenced by hypodermic mercurialisation. In cases accompanied by severe marasmus, the hypodermic use of mercury is contra-indicated. It is also inappropriate to the treatment of those persons who have to be treated as _out_patients of a hospital. Stöhr employs a solution of corrosive sublimate in distilled water: he had at first tried a solution in glycerine, but this did not prove practically convenient. The dose ordinarily used was ⅛ of a grain; the daily employment of this only slowly produces ptyalism. When ¼ grain doses were used daily, the