slighter symptoms of ptyalism never failed to occur by the third or fourth day, and the severer phenomena by the eighth or ninth; so that, with few exceptions, the administration of 2 or 2½ grains in this way produced such a strong development of salivation that the treatment had to be interrupted. (_Deutsches Archiv f. klin. Med._ V. 3 and 4.) =The Treatment of Diabetes.=—Dr. Leube gives an elaborate report of two cases of diabetes in which he made the most careful daily observations of the quantity of water, of sugar, &c. He arrives at the following therapeutic conclusions:—Pure meat diet (with only _almond_ bread) was the most powerful means of reducing the sugar excretion. Of drugs which were tried, _arsenic_ had by far the most remarkable effect in reducing the sugar. Saikowsky discovered, some three years ago, that the continuous administration of arsenic for several days to animals entirely removed all glycogen from the liver; and that then neither puncture of the fourth ventricle nor curara poisoning would produce diabetes at all. Leube made the therapeutical application of the drug which these experiments suggest. He administered Fowler’s solution in doses equivalent to about ⅓ grain of arsenic daily. The effects were most striking during the period when the patients were taking a _mixed_ diet. With mixed diet, and without arsenic, the daily average of sugar was 570 grammes in one case; arsenic reduced it to 352 grammes, on the average of 79 day and night observations; and substantially the same result was obtained in the other case. The use of this drug would appear to promise results of real importance. (_Deutsches Archiv f. klin. Med._ V. 3 and 4.)