THE DOSE OF ATROPIA FOR SUBCUTANEOUS INJECTION.—I wish to answer the query of Dr. Sisson in the _Practitioner_ of last month with every caution, but I have formed a strong opinion on the subject in question. A “Country Practitioner,” who wrote to this journal in February, states that he used to give hypodermic injections of more than ⅕ grain of atropia daily, to the same patient, for years. Now I stated in my paper in this journal (July 1868), that such doses as these are utterly unsafe, and I retain that opinion. Supposing that the sulphate of atropia was good, which it is very possible it was not in the “Country Practitioner’s” case, I can affirm, from my own knowledge, that there are many patients to whom such a dose would be dangerous and probably fatal, if it were really fairly introduced into the subcutaneous tissue. _I have seen uncomfortable atropism from the injection of less than 1/100 grain_: a case occurred to me only a week or two since. It is therefore unadvisable to begin, at any rate, with large doses. With a large experience of subcutaneous injection, I am enabled to say with confidence that 1/60 or 1/50 grain doses are what are best borne by the majority of persons; that sometimes, but not often, it is necessary to go as far as 1/30 grain; and that not unfrequently patients will not bear as much as the 1/60 without uncomfortable atropism. Hence my recommendation to practitioners to commence, experimentally, with such a small quantity as the 1/120 grain.—F. E. ANSTIE.