It has already been remarked that it is possible for "spot" disease to develop in dry rubber which previously gave no evidence of the presence of fungi. The condition necessary to such an occurrence is supplied by the presence of moisture. Thus, to state instances which are by no means uncommon, if a box of rubber is allowed to remain exposed to rain, or is damaged by flood-water, or by sea-water during transit, or (sometimes) if the rubber is packed in a damp case, the crepe on arrival at its destination may be found to be affected to a degree dependent upon the extent of wetting and the duration of the wetting period. No means are known by which these coloured spots, due to the growth of chromogenic organisms, can be removed from the rubber. Naturally, although they may be present in the darker lower grades of crepe, they are not so easily visible as in pale crepe. It follows, therefore, that every possible precautionary measure must be taken when pale crepe has to be prepared. We are often asked whether it is possible for an infected piece of rubber to affect sound rubber hanging in the same building; and whether, in case of "spot" disease appearing, it is necessary to disinfect the drying-house. In a general sense, the answer to both queries is in the negative. It has not been proved possible to transmit the disease from one piece of crepe to another, except by the closest possible contact and in the presence of an abundance of moisture. A dry crepe, even when in close contact with an infected dry specimen, has not been found to be affected. Unless, therefore, pieces of rubber are pressed together, under favourable conditions as to moisture, there has been observed no transfer of disease. Similarly it has not been found that the presence of spotted rubber in one part of the drying-house has been responsible for an outbreak of disease in another part of the same building. Furthermore, after the removal of diseased rubber from the drying-shed, freshly prepared rubber may be hung on the same supports without becoming affected, and without any intermediate treatment of the wooden bars, providing the crepe is thin and weather conditions are good. In our experience, no case has been observed in which the disease has been communicated to freshly prepared rubber by reason of the previous presence of affected rubber. In our opinion, therefore, any scheme for disinfecting the interior of a drying-house, as a preventive measure against the spread of "spot" disease, is unnecessary. All other things being equal, it is plain that much will depend, as to the incidence of coloured spots, upon the design and situation of the drying-house. Sufficient has been written in previous chapters to indicate the importance of these points as affecting the rate of drying, upon which hinges the possibility of the appearance of "spot" disease. In conclusion, the chief points in any discussion of this subject may be summarised thus: