Virus obtained from the brain or cord and inoculated into the dura of another animal quickly precipitates the disease. It is, moreover, modified in virulence as it passes through successive animals of certain species--for example, monkeys. It is increased by passage through rabbits, and the period of incubation thereby shortened. The weakest virus can by proper handling and manipulation in this way be so intensified as to produce disease within seven days after inoculation. Desiccation reduces the virulence, and preparations from the cord of an infected animal may be attenuated to almost any desired extent by drying. By inoculating a dog or a rabbit with virus prepared from this weakened source, and daily making injections from stronger and stronger preparations, it is in the course of a couple of weeks rendered practically immune to the disease. Animals thus made immune are trephined and the virus injected beneath the dura, by which more certain results are obtained. The treatment consists in using a section of a rabbit’s spinal cord, 0.5 Cm. in length, rubbed up in 6 Cc. of sterile salt solution. Half of this amount is injected each day into the flank of the patient. The cord first used is one that is thirteen or fourteen days old, which has been kept suspended in a sterile flask, over caustic potash, in order to assist in its desiccation. The next day a cord one day younger is used, and so on until by the twelfth day of treatment the cord is one only two days old, and at the end of two weeks a fresh cord can be used which would convey the disease had it been used first. If this course of treatment can be carried through before the first symptoms of the disease appear, the antidote has gained complete mastery over the infecting agent and the patient is saved. GLANDERS AND FARCY. Glanders as it is known in man is a _specific infectious disease, transmitted usually from the horse, characterized by rapid formation of specific granulomas_, particularly in the skin and mucous membranes, _which quickly break down into ulcers_, and by the general toxemia characteristic of any acute infection. In German it is known as _Rotz_, in French as _morve_, while its old Latin name was “malleus” (hence we speak of the _bacillus mallei_). It was also known in former days as _equinia_. In horses the disease has also been known as _farcy_, because of the peculiar subcutaneous nodules which farriers and hostlers, almost from time immemorial, have called “farcy buds.” The disease, while capable of transmission from man to man, is generally produced by contagion from some of the domestic animals, most commonly the horse, although sheep and goats are known to occasionally have it, and dogs are susceptible, though seldom showing manifestations of it.