The principles and practice of modern surgeryPark, Roswell
Science
The principles and practice of modern surgery
Park, Roswell
Surgery
The consequence of this endothelial activity is new cell formation and
the construction of a projection from the capillary which soon attains
the dignity of its parent vessel, and, as connective-tissue cells form
around it, soon becomes a granulation by itself, each granulation being
marked by a capillary loop of its own. Healing by granulation or the
granulation process, no matter how set up or caused, is essentially
the formation of hundreds or thousands of these tiny structures, a
new one being formed on top of those which precede it, while those
first formed and deeper down undergo condensation and metamorphosis
of tissues, by which they are converted into something higher in
the tissue scale. Under ideal conditions true granulation building
proceeds _pari passu_ with epithelial reproduction around the margin
of the granulating surface, so that by the time granulation tissue
has completely filled the defect, no matter how caused, epithelial
covering has been completely constructed and the healing process thus
completed. These two processes, however, do not necessarily keep pace
with each other. Should surface repair take place relatively early,
we may have a depressed scar; while, on the other hand, should it not
proceed rapidly enough, or, to state it in another way, should the
granulating process be too rapid, we have such excess of granulations
as shall rise considerably above the surrounding level, and may, under
certain circumstances, become so exuberant that nutritive material
cannot be formed rapidly enough, and those granulations farthest away
from the centre of supply may die. Such exuberant granulation is often
spoken of as _fungoid_, and constitutes that great bugbear in the eyes
of the laity which is termed by them _proud flesh_. It has no further
significance than that the supply has exceeded the demand and that the
granulating process has been overdone. Such luxuriant granulations may
be cut away with scissors or knife, may be burned away with caustic
agents or the actual cautery, or may be disposed of in any other manner
without harm and only with benefit; in fact, it is often necessary to
suppress this exuberant tendency by caustics and pressure, in order
that the desired epithelial covering may be properly formed.
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