§ 95. The interpretation which it affords of sundry phenomena familiar to breeders of animals, adds probability to the hypothesis. Mr. Darwin has collected a large "body of facts, showing, in accordance with the almost universal belief of breeders, that with animals and plants a cross between different varieties, or between individuals of the same variety but of another strain, gives vigour and fertility to the offspring; and on the other hand, that _close_ interbreeding diminishes vigour and fertility,"--a conclusion harmonizing with the current belief respecting family-intermarriages in the human race. Have we not here a solution of these facts? Relations must, on the average of cases, be individuals whose physiological units are more nearly alike than usual. Animals of different varieties must be those whose physiological units are more unlike than usual. In the one case, the unlikeness of the units may frequently be insufficient to produce fertilization; or, if sufficient to produce fertilization, not sufficient to produce that active molecular change required for vigorous development. In the other case, both fertilization and vigorous development will be made probable. Nor are we without a cause for the irregular manifestations of these general tendencies. The mixed physiological units composing any organism being, as we have seen, more or less segregated in the reproductive centres it throws off; there may arise various results according to the degrees of difference among the units, and the degrees in which the units are segregated. Of two cousins who have married, the common grandparents may have had either similar or dissimilar constitutions; and if their constitutions were dissimilar, the probability that their married grandchildren will have offspring will be greater than if their constitutions were similar. Or the brothers and sisters from whom these cousins descended, instead of severally inheriting the constitutions of their parents in tolerably equal degrees, may have severally inherited them in very different degrees: in which last case, intermarriages among the cousins will be less likely to prove infertile. Or the brothers and sisters from whom these cousins descended, may severally have married persons very like, or very unlike, themselves; and from this cause there may have resulted, either an undue likeness, or a due unlikeness, between the married cousins.[39] These several causes, conspiring and conflicting in endless ways and degrees, will work multiform effects. Moreover, differences of segregation will make the reproductive centres produced by the same nearly-related organisms, vary considerably in their amounts of unlikeness; and therefore, supposing their amounts of unlikeness great enough to cause fertilization, this fertilization will be effective in various degrees. Hence it may happen that among offspring of nearly-related parents, there may be some in which the want of vigour is not marked, and