Consider one of the simplest--that presented by an ordinary vegetal cell forming part of a leaf or other plant-structure. Its limiting membrane, originally made polyhedral by pressure of adjacent cells, is gradually moulded "into one of cylindrical, fibrous, or tabular shape, and strengthening its walls with pilasters, borders, ridges, hooks, bands, and panels of various kinds" (Kerner, i, 43): small openings into adjacent cells being either left or subsequently made. Consisting of non-nitrogenous, inactive matters, these structures are formed by the inclosed protoplast. How formed? Is it by the agency of the nucleus? But the nucleus, even had it characters conceivably adapting it to this function, is irregularly placed; and that it should work the same effects upon the cell-wall whether seated in the middle, at one end, or one side, is incomprehensible. Is the protoplasm then the active agent? But this is arranged into a network of strands and threads utterly irregular in distribution and perpetually altering their shapes and connexions. Exercise of fit directive action by the protoplasm is unimaginable. Another instance:--Consider the reproductive changes exhibited by the _Spirogyra_. The delicate threads which, in this low type of Alga, are constituted of single elongated cells joined end to end, are here and there adjacent to one another; and from a cell of one thread and a cell of another at fit distance, grow out prominences which, meeting in the interspace and forming a channel by the dissolution of their adjoined cell-walls, empty through it the endochrome of the one cell into the other: forming by fusion of the two a zygote or reproductive body. Under what influence is this action initiated and guided? There is no conceivable directive agency in either cell by which, when conditions are fit, a papilla is so formed as to meet an opposite papilla. Or again, contemplate the still more marvellous transformation occurring in _Hydrodictyon utriculosum_. United with others to form a cylindrical network, each sausage-shaped cell of this Alga contains, when fully developed, a lining chromatophore made of nucleated protoplasm with immersed chlorophyll-grains. This, when the cell is adult, divides into multitudinous zoospores, which presently join their ends in such ways as to form a network with meshes mostly hexagonal, minute in size, but like in arrangement to the network of which the parent cell formed a part. Eventually escaping from the mother-cell, this network grows and presently becomes as large as the parent network. Under what play of forces do these zoospores arrange themselves into this strange structure?