So that throughout physiological development, as in evolution at large, the multiplication of effects has been a factor constantly at work, and working more actively as the development has advanced. The secondary changes wrought by each primary change, have necessarily become more numerous in proportion as organisms have become more complex. And every increased multiplication of effects, further differentiating the organism and, by consequence, further integrating it, has prepared the way for still higher differentiations and integrations similarly caused. § 313. The general truth next to be resumed, is that these processes have for their limit a state of equilibrium--proximately a moving equilibrium and ultimately a complete equilibrium. The changes we have contemplated are but the concomitants of a progressing equilibration. In every aggregate which we call living, as well as in all other aggregates, the instability of the homogeneous is but another name for the absence of balance between the incident forces and the forces which the aggregate opposes to them; and the passage into heterogeneity is the passage towards a state of balance. And to say that in every aggregate, organic or other, there goes on a multiplication of effects, is but to say that one part which has a fresh force impressed on it, must go on changing and communicating secondary changes, until the whole of the impressed force has been used up in generating equivalent reactive forces. The principle that whatever new action an organism is subject to, must either overthrow the moving equilibrium of its functions and cause the sudden equilibration called death, or else must progressively alter the organic rhythms until, by the establishment of a new reaction balancing the new action a new moving equilibrium is produced, applies as much to each member of an organism as to the organism in its totality. Any force falling on any part not adapted to bear it, must either cause local destruction of tissue, or must, without destroying the tissue, continue to change it until it can change it no further; that is--until the modified reaction of the part has become equal to the modified action. Whatever the nature of the force this must happen. If it is a mechanical force, then the immediate effect is some distortion of the part--a distortion having for its limit that attitude in which the resistance of the structures to further change of position, balances the force tending to produce the further change; and the ultimate effect, supposing the force to be continuous or recurrent, is such a permanent alteration of form, or alteration of structure, or both, as establishes a permanent balance. If the force is physico-chemical, or chemical, the general result is still the same: the component molecules of the tissue must have their molecular arrangements changed, and the change in their molecular arrangements must go on until their molecular