One of the most remarkable and beneficial reforms of the century has been in the attitude of the profession and the public to the subject of insanity, and the gradual formation of a body of men in the profession who labor to find out the cause and means of relief of this most distressing of all human maladies. The reform movement inaugurated by Tuke in England, by Rush in the United States, by Pinel and Esquirol in France, and by Jacobi and Hasse in Germany, has spread to all civilized countries, and has led not only to an amelioration and improvement in the care of the insane, but to a scientific study of the subject which has already been productive of much good. In this country, while the treatment of the insane is careful and humanitarian, the unfortunate affiliation of insanity with politics is still in many States a serious hinderance to progress. It may be interesting to take a glance at the state of medicine in this country at the opening of the nineteenth century. There were only three schools of medicine, the most important of which were the University of Pennsylvania and the Harvard. There were only two general hospitals. The medical education was chiefly in the hands of the practitioners, who took students as apprentices for a certain number of years. The well-to-do students and those wishing a better class of education went to Edinburgh or London. There were only two or three medical journals, and very few books had been published in the country, and the profession was dependent entirely upon translations from the French and upon English works. The only medical libraries were in connection with the Pennsylvania Hospital and the New York Hospital. The leading practitioners in the early years were Rush and Physick, in Philadelphia; Hossack and Mitchill, in New York; and James Jackson and John Collins Warren, in Boston. There were throughout the country, in smaller places, men of great capabilities and energy, such as Nathan Smith, the founder of the Medical Schools of Dartmouth and of Yale, and Daniel Drake in Cincinnati. After 1830 a remarkable change took place in the profession, owing to the leaven of French science brought back from Paris by American students. Between 1840 and 1870 there was a great increase in the number of medical schools, but the general standard of education was low—lower, indeed, than had ever before been reached in the medical profession. The private schools multiplied rapidly, diplomas were given on short two-year sessions, and nothing contributed more to the degeneration of the profession than this competition and rivalry between ill-equipped medical schools. The reformation, which started at Harvard shortly after 1870, spread over the entire country, and the rapid evolution of the medical school has been one of the most striking phenomena in the history of medicine in the century. University authorities began to appreciate the fact that medicine was a great department of knowledge, to be cultivated