The preceding false reports, though no longer circulated, have never been definitely withdrawn and while it is now generally conceded that the good results in anemia are obtained by the administration of the various simple inorganic iron preparations the Breitenbach Company still attempts to convey the impression that Pepto-Mangan (Gude) is of most superior efficacy. Thus the present Pepto-Mangan circular attempts to discredit by obsolete and absurd or untrue statements the various preparations of iron which are in general use and to carry the impression that only iron and manganese, in the particular form and proportion in which they are contained in Pepto-Mangan--namely, 3 parts Fe to 1 part Mn--are useful for the treatment of anemia, chlorosis, etc. Thus contrary to general conceptions, the impression is given that the now generally accepted course of chlorosis is due to the three varieties of insufficiency of certain blood elements: (1) insufficiency of manganese, (2) insufficiency of iron, (3) insufficiency of iron and manganese; and that the administration of iron often fails because manganese is not supplied to the system at the same time and in sufficient amounts. The following statement is made: “Doctor: “If you have a case of ANAEMIA, CHLOROSIS, or AMENORRHOEA, that shows no visible sign of improvement, and you have exhausted the entire list of Nauseating Iron preparations with little or no effect, it is because the blood is deficient in that _essential oxidizing constituent_, _MANGANESE_, in a soluble, readily assimilable form, the best being in combination with iron.” Another extravagant claim: “Usually after taking it for a week its restorative influence on the functions of the stomach is felt; appetite reappears, and the general health is improved by the increase in bodily warmth, an effect directly due to manganese.” The following statement implies that Pepto-Mangan is absorbed unchanged, for which there is no justification: “As the ferruginous and manganic ingredients of Pepto-Mangan (Gude) exist in the form of organic peptonates, they have already undergone the changes necessary to insure prompt absorption and appropriation by the circulating fluid.” The following declaration implies that it repairs the individual defective blood-cells which is, of course, also ridiculous: “That Pepto-Mangan (Gude) quickly and efficiently builds up defective red blood cells, and generates, or at least potently encourages the formation of new ones, and materially increases their richness in hemoglobin, has been abundantly demonstrated....”