The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2Council on Pharmacy and Chemistry (American Medical Association)
Science
The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2
Council on Pharmacy and Chemistry (American Medical Association)
Patent medicines
Under petrolatum liquidum the U. S. P. recognizes a mixture of
hydrocarbons, chiefly of the methane series, which occurs as a
colorless or very slightly yellowish, oily, transparent liquid without
odor or taste and having a specific gravity of about 0.870 to 0.940 at
25 C. For the U. S. P. IX, it is proposed to change this requirement
somewhat so as to have it apply to a transparent liquid free from
fluorescence, without odor or taste and having a specific gravity of
from 0.845 to 0.940 at 25 C.
Such a requirement would include all of the available paraffin oils
irrespective of origin. The now commonly available commercial liquid
petrolatum, used for pharmaceutical purposes, is practically colorless
and all of the better grades are free from odor or taste. The specific
gravity varies from 0.855 to 0.895. The lighter oils, having a specific
gravity of from 0.860 to 0.870, are usually preferred in the making of
oil sprays or solutions of substances to be used as local applications.
The product having a specific gravity above 0.875 evidently contains
a considerable amount of dissolved solid paraffin which separates
out at temperatures at or below 0 C., but readily dissolves again at
temperatures above 10 C.
There is considerable difference in the chemical composition of the
paraffin oils obtained from various sources. The American oil consists
largely of hydrocarbons of the methane series, while the Russian oil
contains naphthenes or hydrocarbons of the benzene series, having
the empirical composition of ethylene, (C_{n}H_{2n}) which may be
considered as hydrogenated aromatic hydrocarbons, though they behave
with reagents very much in the same way as do the hydrocarbons of the
methane series.
Mineral oils with a naphthene base are best suited for making white
petrolatum, and at the present time the production of the colorless
water-white liquid petrolatum appears to be confined largely or almost
exclusively to the crude product of the Baku district of Russia, though
it is asserted that it is now also made from the Hanover (Germany)
crude oil and that some is being produced by “cracking” the white solid
paraffin.
It is also said that the American oil can be made water white but
that it is not being so produced at present for economic reasons; the
yellowish oil, free from fluorescence, having a very wide sale, both
as a lubricant and as a substitute for lard oil and other of the more
costly lubricating oils.
From a pharmaceutical point of view it would appear important to note
the physical characteristics of the oil and to insist on absence of
color, absence of odor and taste, absence of acid and of alkali and a
specific gravity in harmony with the purposes for which the oil is to
be used.
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Elsewhere in the archive
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account