The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2Council on Pharmacy and Chemistry (American Medical Association)
Science
The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2
Council on Pharmacy and Chemistry (American Medical Association)
Patent medicines
“... a comparatively non-toxic organic arsenic compound, 0.6 Gm.,
representing 247 Mg. (3-3/4 grains) of metallic arsenic and .78 Mg.
(3/250 grain) metallic mercury in chemical combination.”
Neither one of these statements gives any information as to the actual
composition of the product. Inquiry addressed to the manufacturers
elicited the reply that:
“Venarsen contains in each 5 c.c. 0.6 Gm. Sodium Dimethyl Arsenate,
.0016 grams of Mercuric Iodide, .0048 grams of Sodium Iodide in
solution in a suitable vehicle for intravenous administration.”
The following report of the examination of Venarsen is submitted by the
Association’s Chemical Laboratory:
LABORATORY REPORT
Three ampules of Venarsen were examined. The first ampule was labeled
“A comparatively non-toxic organic arsenic compound, representing
247 Mg. (3-3/4 grs.) of metallic arsenic in chemical combination. 5
c.c.--0.6 Gm.”
Practically the same statement appeared in an advertising circular
wrapped around the ampule. The second and third ampules bore labels
identical with the first. The circulars differed from that accompanying
the first ampule in that the presence of mercury is also announced,
thus:
“Venarsen is a comparatively non-toxic organic arsenic compound,
0.6 Gm., representing 247 Mg. (3-3/4 grains) of metallic arsenic
and .78 Mg. (3/250 grain) metallic mercury in chemical combination
and is so prepared and enhanced as to present the ingredients to
the blood in their most acceptable form.”
Thus, although the potent elements said to be contained in Venarsen are
named, its chemical character (the combination in which the elements
occur) is not disclosed.
The ampules contained a transparent, odorless solution, possessing
the yellow color of salvarsan solution (an aqueous solution of sodium
cacodylate, mercuric iodid and sodium iodid in the amounts said to
be present in Venarsen is colorless). Qualitative tests demonstrated
the presence in each of the three ampules of sodium cacodylate
(sodium dimethyl arsenate), and the absence of arsenites, arsenates,
phosphates, arsanilates (atoxyl, soamin) and arsenphenolamins
(salvarsan, neosalvarsan). Titrated with normal hydrochloric acid,
using methyl orange as indicator (as outlined in New and Nonofficial
Remedies, 1915, p. 40), the three ampules were found to contain the
equivalent of respectively, 0.219, 0.253 and 0.216 Gm., or an average
of 0.244 Gm. arsenic. (According to statements of the firm each
5 c.c. of Venarsen contains 0.6 Gm. sodium dimethyl arsenate [sodium
cacodylate], equivalent to 0.247 Gm. arsenic or 41.66 per cent. Sodium
dimethyl arsenate, as described in New and Nonofficial Remedies,
contains 3 molecules of water and 35 per cent. arsenic. This indicates
that the sodium dimethyl arsenate used in Venarsen contains less water
of crystallization than the N. N. R. product).
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