“In the opinion of the present referee there is nothing in the composition of Virol to justify the claims made for it. The judgment and recommendations of the first referee follow from the facts and must be accepted by the Council.” The Council directed that the previously prepared report be allowed to stand and that it be published along with a suitable reference to the report of the second referee.--(_From The Journal A. M. A., Feb. 20, 1915._) PART II CONTRIBUTIONS FROM THE CHEMICAL LABORATORY ANUSOL HEMORRHOIDAL SUPPOSITORIES[AO] W. A. Puckner and L. E. Warren [AO] See also Anusol Suppositories, p. 280. An abstract of an article concerning “anusol suppositories” was published in The Journal, Jan. 23, 1909. This gave the results of an analysis by a foreign chemist, J. F. Suyver, which were to the effect that “anusol suppositories” contained no “anusol.” Schering & Glatz, the American agents for “anusol” suppositories, took exceptions to the abstract, asked that The Journal retract, and submitted the findings of a chemist in support of their claim that the suppositories do contain “anusol.” To determine the composition of “anusol hemorrhoidal suppositories” as they are found on the American market, trade packages were purchased (April 6, 1909) and submitted to examination[90] in the Association’s laboratory. [90] Details of the quantitative analysis of “Anusol Hemorrhoidal Suppositories” appear in the annual report for 1909 of the Chemical Laboratory of the American Medical Association. According to the claims of the manufacturers, 12 suppositories contain: “Anusoli 7.5 grams. “Zinc oxid 6.0 grams “Balsam Peruv 1.5 grams “Ol. theobrom 19.0 grams “Ungt. cerat 2.5 grams” Calculated to percentages the formula reads: Anusoli 20.54 per cent. Zinc oxid 16.44 per cent. Balsam Peruv 4.11 per cent. Ol. theobrom 52.06 per cent. Ungt. cerat 6.85 per cent. When this product was submitted to the Council some time ago, Schering & Glatz stated that, according to the manufacturer, “anusol” is the “iodo resorcin sulphonate of bismuth, having the following rational formula: [C_{6}H_{2}ISO_{2}.O(OH)_{2}]_{3}Bi. In the meta-dioxybenzol C_{6}H_{4}(OH)_{2}, the resorcin, one H has been replaced by one I, and for another H the sulfonic-acid group SO_{2}-OH has been substituted, so that meta-dioxybenzol is transformed into C_{6}H_{2}ISO_{2}-OH(OH)_{2}. In the sulfonic acid the H of OH is replaced by Bi and, as Bi is trivalent the above rational formula results.” According to this formula “anusol” should contain: Iodin 32.99 per cent. Sulphur 8.34 per cent. Bismuth 18.07 per cent. And the “anusol” suppositories should contain: